whereRU: Aresty Poster 60 - Antisense Transcription in Yeast Regulates Gene Expression by Aresty Posters 2009

Previous work has shown that the expression of overlapping non-coding RNA (nc-RNA) is a method of transcriptional repression in Saccharomyces cerevisiae. One example of this form of regulation is the control of the meiosis-specific IME4 gene, in which expression of a non-coding antisense transcript, referred to here as RME2 (Repressor of Meiosis), prevents IME4 (Inducer of Meiosis) expression. Mutational analyses have shown a region within the IME4 ORF is required for repression by RME2. RME2 does not appear to disrupt transcription factor binding in the promoter. A similar model of regulation has also been observed for the gene ZIP2, suggesting that this is a conserved mechanism to control gene expression in yeast.
E-mail: napostol@eden.rutgers.edu  ; Lab URL: beadle.rutgers.edu/vershon/Vershon_Lab.html