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About This GigapanToggle
- Taken by
- Aresty Posters 2009
- Explore score
- 0.06 Gigapixels
- Date added
- May 20, 2009
- Date taken
- May 19, 2009
Potential Synergistic Inhibitory Effect of Epigallocatechin-3-gallate and Atorvastatin Combination in Lung Cancer Cell Lines
Bridget Huang, Fei Guan, Zhihong Yang, Chung S. Yang
Department of Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey
164 Frelinghuysen Road
Piscataway, N.J. 08854-0789
Bridget Huang, email@example.com
The principal green tea polyphenol, epigallocatechin-3-gallate (EGCG), and a member of statins family, atorvastatin (ATST, Lipitor), are two chemopreventive agents known to inhibit cancer cell growth. The mechanisms of actions suggest combinatorial treatments of EGCG and ATST have potential synergistic effect in inhibition of tumor cell proliferation and mobility. We used cell invasion assay as a mean of cell mobility determination and 67-laminin receptor (67LR) silencing small hairpin RNA for examining EGCG cell mobility inhibition mechanism via 67LR. Individual treatment of EGCG showed decreased cell invasion. EGCG and ATST combination treatments may be a more effective strategy in chemoprevention than single treatments.