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whereRU: Aresty Poster 19 - CPE and NOS1AP in Neuronal Development by Aresty Posters 2009

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Taken by
Aresty Posters 2009 Aresty Posters 2009
Explore score
0.06 Gigapixels
Date added
May 15, 2009
Date taken
May 15, 2009

The Role of CPE and NOS1AP in Neuronal Development

Nitric oxide synthase 1 (neuronal nitric oxide synthase) adaptor protein (NOS1AP) was first identified as a binding partner of neuronal nitric oxide synthase. Recent data obtained in the Firestein laboratory show that overexpression of NOS1AP-long (one of the isoforms) produces a significant reduction of primary and secondary dendrite numbers via an interaction with carboxypeptidase E (CPE). Knocking down CPE attenuates the effect of NOS1AP overexpression in decreasing dendrite numbers, suggesting that this decrease occurs in a CPE-dependent manner. Biochemical and cell biological data confirm that NOS1AP binds to CPE under physiological conditions. Thus, our data suggest that NOS1AP and CPE are part of a signaling pathway that regulates dendrite morphology.

Gregory Zegarek, Munjin Kwon, and Bonnie Firestein


More Information can be found at lifesci.rutgers.edu/~firestein Will open in a new tab or window/

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