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whereRU: Aresty Poster 19 - CPE and NOS1AP in Neuronal Development by Aresty Posters 2009

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Aresty Posters 2009 Aresty Posters 2009
Explore score
1
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0.06 Gigapixels
Views
538
Date added
May 15, 2009
Date taken
May 15, 2009
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The Role of CPE and NOS1AP in Neuronal Development

Nitric oxide synthase 1 (neuronal nitric oxide synthase) adaptor protein (NOS1AP) was first identified as a binding partner of neuronal nitric oxide synthase. Recent data obtained in the Firestein laboratory show that overexpression of NOS1AP-long (one of the isoforms) produces a significant reduction of primary and secondary dendrite numbers via an interaction with carboxypeptidase E (CPE). Knocking down CPE attenuates the effect of NOS1AP overexpression in decreasing dendrite numbers, suggesting that this decrease occurs in a CPE-dependent manner. Biochemical and cell biological data confirm that NOS1AP binds to CPE under physiological conditions. Thus, our data suggest that NOS1AP and CPE are part of a signaling pathway that regulates dendrite morphology.

Gregory Zegarek, Munjin Kwon, and Bonnie Firestein

gzegarek@gmail.com

More Information can be found at lifesci.rutgers.edu/~firestein Will open in a new tab or window/


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