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About This GigaPan
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Aresty Posters 2009
- Explore score
- 1
- Size
- 0.06 Gigapixels
- Views
- 419
- Date added
- May 15, 2009
- Date taken
- May 15, 2009
- Categories
- Galleries
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- Tags
- aresty, posters, 2009, undergraduate, rutgers, whereru, infovis
- Description
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The Role of CPE and NOS1AP in Neuronal Development
Nitric oxide synthase 1 (neuronal nitric oxide synthase) adaptor protein (NOS1AP) was first identified as a binding partner of neuronal nitric oxide synthase. Recent data obtained in the Firestein laboratory show that overexpression of NOS1AP-long (one of the isoforms) produces a significant reduction of primary and secondary dendrite numbers via an interaction with carboxypeptidase E (CPE). Knocking down CPE attenuates the effect of NOS1AP overexpression in decreasing dendrite numbers, suggesting that this decrease occurs in a CPE-dependent manner. Biochemical and cell biological data confirm that NOS1AP binds to CPE under physiological conditions. Thus, our data suggest that NOS1AP and CPE are part of a signaling pathway that regulates dendrite morphology.
Gregory Zegarek, Munjin Kwon, and Bonnie Firestein
gzegarek@gmail.com
More Information can be found at lifesci.rutgers.edu/~firestein
/
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